In the traditional tests for antipsychotic effect, eg antagonism of stereotypic behaviour induced by dopamine agonists, the chemical groups of antipsychotics mentioned reveal equal but dosage-dependent activity. However, the antistereotypic effects of phenothiazines, butyrophenones, diphenylbutylpiperidines, and benzamides is strongly counteracted by the anticholinergic drug scopolamine, while the antistereotypic effect of thioxanthenes, eg flupentixol is not, or only very slightly, influenced by concomitant treatment with anticholinergics.
Fluphenazine came into use in 1959.  The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  It is available as a generic medication .  In the United States the tablets costs between and USD per day for a typical dose.  The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014.  It was discontinued in Australia around mid 2017. 
People with schizophrenia are particularly vulnerable and need social supports decent housing, income support, supportive friends and family, and something worthwhile to do. Most people with schizophrenia become ill at the age they would be making career choices, undergoing training and forming adult relationships. As a result, they often lack social and work skills. So in addition to medication, people with schizophrenia may need training in social skills, money management and problem-solving. Those who can work often need further training and employment support.