Haldol decanoate starting dose

In pharmacokinetic studies, mild to moderately increased haloperidol concentrations have been reported when haloperidol was given concomitantly with drugs characterized as substrates or inhibitors of CYP3A4 or CYP2D6 isoenzymes, such as itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, and promethazine.

When prolonged treatment (1 to 2 weeks) with enzyme-inducing drugs such as rifampin or carbamazepine is added to haloperidol therapy, this results in a significant reduction of haloperidol plasma levels.

Rifampin
In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline. In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean -fold increase in haloperidol concentrations.

Carbamazepine
In a study in 11 schizophrenic patients co-administered haloperidol and increasing doses of carbamazepine, haloperidol plasma concentrations decreased linearly with increasing carbamazepine concentrations.

Thus, careful monitoring of clinical status is warranted when enzyme inducing drugs such as rifampin or carbamazepine are administered or discontinued in haloperidol-treated patients. During combination treatment, the haloperidol dose should be adjusted, when necessary. After discontinuation of such drugs, it may be necessary to reduce the dosage of haloperidol.

Valproate
Sodium valproate, a drug known to inhibit glucuronidation, does not affect haloperidol plasma concentrations.

Given these considerations, antipsychotic drugs should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that 1) is known to respond to antipsychotic drugs, and 2) for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically.

The Mellon family were the founders of the original Mellon Institute whence came the "amazing (but totally fallacious) sodium fluoride/dental caries prevention discovery" - the discovery that literally turned 'garbage into gold'. The Mellon family also founded the American Aluminum Company (Alcoa), the largest producer of the waste toxin, sodium fluoride, which, up to this point of 'caries discovery', had relatively little known commercial or industrial value, was an environmental hazard of great public concern, and was very costly in terms of safe disposal.

In order to determine whether the diagnosis of a psychotic disorder is warranted, the health care professional has to first consider if a medical illness may be the cause of the behavioral changes. If a medical disease is identified or the psychosis is found to be the result of exposure to a medication or drug, the sufferer is assessed as having psychotic disorder due to a medical condition or psychotic disorder due to toxin exposure or withdrawal, respectively. On the other hand, if a medical cause and toxin exposure have been looked for and not found, a psychotic illness such as schizophrenia could be considered. The diagnosis will best be made by a licensed mental-health professional (like a psychiatrist or clinical psychologist), who can evaluate the patient and carefully sort through the diagnostic criteria for a variety of mental illnesses that might look alike at the initial examination, like schizotypal or schizoid personality disorder or a mood disorder with psychotic features like severe depression , or the mania phase of bipolar disorder. Other health care professionals who may treat psychotic disorders may include licensed social workers, psychiatric nurses and nurse practitioners, mental health physician assistants, and sometimes non-psychiatric physicians.

Haldol decanoate starting dose

haldol decanoate starting dose

In order to determine whether the diagnosis of a psychotic disorder is warranted, the health care professional has to first consider if a medical illness may be the cause of the behavioral changes. If a medical disease is identified or the psychosis is found to be the result of exposure to a medication or drug, the sufferer is assessed as having psychotic disorder due to a medical condition or psychotic disorder due to toxin exposure or withdrawal, respectively. On the other hand, if a medical cause and toxin exposure have been looked for and not found, a psychotic illness such as schizophrenia could be considered. The diagnosis will best be made by a licensed mental-health professional (like a psychiatrist or clinical psychologist), who can evaluate the patient and carefully sort through the diagnostic criteria for a variety of mental illnesses that might look alike at the initial examination, like schizotypal or schizoid personality disorder or a mood disorder with psychotic features like severe depression , or the mania phase of bipolar disorder. Other health care professionals who may treat psychotic disorders may include licensed social workers, psychiatric nurses and nurse practitioners, mental health physician assistants, and sometimes non-psychiatric physicians.

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