Make no mistake, embarking on the hormone injection wagon is a serious commitment. Your doctor can teach you and your partner to administer the injections (typically in your thigh) so you don’t have to drive to a clinic every day. However, you will need to be available for routine appointments for ultrasounds and bloodwork so your doctor can monitor your hormone levels and to see how your eggs are maturing. In most cases, you will need to take the injections once a day, for up to 12 days, depending on how long it takes for your eggs to mature.
Body weight: Less than or equal to 25 kg: mg IM once a month
Body weight: Greater than 25 kg to kg: mg IM once a month
Body weight: Greater than kg: 15 mg IM once a month
-Hormonal levels should be tested after 1 to 2 months of therapy and with each dose change to ensure adequate pituitary gonadotropin suppression.
-Once a dose that results in adequate hormonal suppression, it can often be maintained for the duration of therapy in most children; however, hormonal suppression should be verified as weight can increase significantly while on therapy.
Initial dose: 50 mcg/kg/day subcutaneously. If total downregulation is not achieved, the dose should be titrated upward by 10 mcg/kg/day. This dose will be considered the maintenance dose.
-The dosage should be adjusted for weight changes.
-Discontinuation of therapy be considered before age 11 for females and before age 12 for males.
Use: Treatment of children with central precocious puberty (CPP)