Low testosterone during puberty

Testosterone is a steroid hormone produced in the adrenal glands of both sexes and in the testes of males and the ovaries of females. Testosterone is largely responsible for the formation and maintenance of male sex characteristics, including both the larger bone and muscle development seen in males. The testosterone levels in humans are regulated by hormones released from the brain; in males the hypothalamus and pituitary glands in the brain increase testosterone during puberty and male characteristics develop (for example, penile enlargement, facial hair, interest in sex).

There are several relatively simple lifestyle changes a woman can make that might elevate T levels. Most obviously, if a woman believes her birth control pills are causing a problem and she feels she can adjust to a different type of birth control, she might stop using them (if indeed she's using them exclusively to prevent conception). She might also reevaluate her need for any of the various medications I mentioned, and perhaps seek alternatives that might not affect testosterone levels. For instance, there's some evidence that the antidepressant wellbutrin actually increases libido, but whether it helps the sex mojo through raising T levels or by some other mechanism isn't well understood.

But I'm not more aggressive—a behavior change often tied to testosterone. That's not surprising to Robert Sapolsky, ., a neuroendocrinologist at Stanford University and a leading researcher on stress and behavior. "It's really not the case that testosterone 'causes' aggressive behavior," he says. "Instead, it makes the brain more sensitive to social cues that trigger aggression. And in support of that, a guy's testosterone level isn't a very good predictor of how likely he is to be aggressive."

A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

Low testosterone during puberty

low testosterone during puberty

A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

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