Anabolic Steroids for Sport
The hypoglycemic action of glyburide is due to stimulation of pancreatic islet cells, which results in an increase in insulin secretion. Sulfonylureas are believed to bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, thereby reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. The drug is not effective in the absence of functioning beta-cells, as occurs in diabetes mellitus type 1, or when the number of viable beta-cells is low, as occurs in severe cases of diabetes mellitus type 2.
Prolonged administration of glyburide also produces extrapancreatic effects that contribute to its hypoglycemic activity. These effects include reduction of basal hepatic glucose production and an enhanced peripheral sensitivity to insulin secondary to an increase in insulin receptors or to changes in the events that follow insulin-receptor binding. The relative importance of each of these actions to the overall therapeutic effect of the drug will vary among oral antidiabetic agents and from patient to patient, which may account for the variability in potency among these drugs. Like glipizide, glyburide exhibits mild diuretic actions but does not affect uric acid concentrations.
Many athletes, ball players, fighters, and any athlete who could benefit from the therapeutic relief often supplement with Deca Durabolin. Such individuals commonly have no desire to build any new lean muscle mass, but the relief alone is invaluable. Further, such relief can be obtained by a very low dose. A slightly higher dose will provide relief, greatly enhance overall recovery, and enhance muscular endurance. When it comes to performance enhancement, most athletes will find this steroid is hard to beat. More importantly, the relief effects of Deca Durabolin are not masking or false; this anabolic steroid shares nothing in common with over the counter painkillers or prescription painkillers like opiates. Such painkillers only mask the pain, whereas Deca Durabolin can actually heal the body.