All anabolic steroids have a tendency to reduce HDL (good) cholesterol and increase LDL (bad) cholesterol. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable) and level of resistance to hepatic metabolism. With regards to nandrolone at a dose of 600mg per week over 10 weeks demonstrated 26% reduction in HDL cholesterol levels. This suppression is slightly greater than an equal dose of testosterone over an equal period. In other words it shows a slightly more negative impact on HDL/LDL ratio with nandrolone than with testosterone cypionate. It’s always recommended to accompany the use of this product with a low saturated fat diet and a cardiovascular exercise program.
Oxandrolone is most certainly a hepatotoxic steroid. It does not carry the strongest level of hepatotoxicity among anabolic steroids, but it is stronger than most. This is due to it being a C17-aa anabolic steroid. All C17-aa steroids are hepatic, but the level of toxicity varies greatly between them. Due to this steroid’s strong hepatotoxicity, this is why total use must be limited (see administration section).
Due to use, those who supplement with Anadrol will find their liver enzyme values increase. An increase in values is not a sign of damage but rather a sign of stress that can lead to damage if responsible practices are not followed and the stress is allowed to remain. Proper dosing and duration of use protocols are imperative when it comes to this steroid. Further, it is important the individual avoids excess alcohol consumption when supplementing with this steroid due to the liver stress such consumption will cause. In fact, most will find avoiding all alcohol to be best during use. If this is a problem and you are supplementing for the purpose of performance enhancement remember there is nothing on earth that is as anti-performance as alcohol. Those who supplement are also encouraged to limit their use of Over the Counter (OTC) medications. Many OTC medications carry strong hepatic natures, and the added stress can be extensive when coupled with Anadrol. Use should be limited to when only absolutely needed. If these rules can be followed, once use is discontinued liver enzyme values will return to normal and no damage will be done. As a final note, Anadrol should not be used if the liver is unhealthy.