In a second study Kundu et al showed that in melanoma cells where PTEN is downregulated, Indole-3-carbinol directly interacts with NEDD4 _1 to prevent PTEN ubiquitination and subsequent proteasomal degradation. This results in stabilization of PTEN and inhibition of proliferation by downstream AKT signaling. Overall scientific evidence shows that in melanoma, Indole-3-carbinol specifically inhibits the two most commonly associated driver mutation signaling pathways to cause antiproliferation, a fact that can be used to design clinical trial to treat human patients with Indole-3-carbinol in future.
Analysis of serum testosterone concentrations from 117 hypogonadal men in the 84-week clinical study of Aveed indicated that serum testosterone concentrations achieved were inversely correlated with the patient's body weight. In 60 patients with pretreatment body weight of ≥ 100 kg, the mean (±SD) serum testosterone average concentration was 426 ± 104 ng/dL. A higher serum testosterone average concentration (568 ± 139 ng/dL) was observed in 57 patients weighing 65 to 100 kg. A similar trend was also observed for maximum serum testosterone concentrations.
Hi Ali: Regarding the mint studies…I just saw this on Suppversity…regarding the difference between mints effects on male and female rats…..Spearmint (M. spicata): At least in women spearmint tea has been shown to increase estrogen and luteinizing hormone in the follicular phase of their menstrual cycle (Aktodgan. 2007). In a 2004 study that was conducted on male rodents, on the other hand, the daily administration of peppermint tea (M. spicata) for a period of 30days lead to significant increases in luteinizing and follicle stimulating hormone and increases in serum testosterone, yet with the serious downside of “extensive degenerative changes in the germinal epithelium and spermatogenesis arrest compared with the findings in the testicular biopsies of the control group” (Aktogan. 2003) interesting for sure!