Testosterone therapy risks

Primary hypogonadism (congenital or acquired): Testicular failure due to diseases and conditions in the body such as cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter Syndrome, chemotherapy, or toxic damage from alcohol or heavy metals; these men usually have low serum testosterone levels and gonadotropins (FSH, LH) above normal range Hypogonadotropic hypogonadism (congenital or acquired): Gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic injury from tumors, trauma, or radiation; these men have low testosterone serum concentrations but have gonadotropins in the normal or low range.

Bone Density: An important factor to consider
In general, the maintenance of healthy bone density in all people is partly dependent on both estrogen and testosterone levels. When an individual's body produces estrogen as its main sex hormone (as in the case of female-bodied people), that estrogen in healthy levels protects against bone loss. If a female-bodied person were to begin testosterone therapy, there would be a time of transition in the body while hormone levels adjust. While testosterone would soon become a more dominant presence in the body of a trans man, he would still retain some estrogen in his system, both through the presence of his ovaries (if he has not had an oophorectomy) and/or via the natural aromatization of testosterone into estrogen (which takes place whether or not the ovaries are still present and functional).

The second theory is similar and is known as "evolutionary neuroandrogenic (ENA) theory of male aggression". [77] [78] Testosterone and other androgens have evolved to masculinize a brain in order to be competitive even to the point of risking harm to the person and others. By doing so, individuals with masculinized brains as a result of pre-natal and adult life testosterone and androgens enhance their resource acquiring abilities in order to survive, attract and copulate with mates as much as possible. [77] The masculinization of the brain is not just mediated by testosterone levels at the adult stage, but also testosterone exposure in the womb as a fetus. Higher pre-natal testosterone indicated by a low digit ratio as well as adult testosterone levels increased risk of fouls or aggression among male players in a soccer game. [79] Studies have also found higher pre-natal testosterone or lower digit ratio to be correlated with higher aggression in males. [80] [81] [82] [83] [84]

Testosterone therapy risks

testosterone therapy risks

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