After cutting out all the junk and getting rid of products that might make users a little too jittery, we were finally able to arrive at our top picks. Of the remaining contenders, we favored those with the highest quantity of effective ingredients and the lowest quantity of superfluous nonsense. If there’s one word to describe our top picks, it’s “well-rounded.” These supplements don’t just rely on one ingredient to get the job done; they pull in everything from creatine to citrulline and round out the package with a nice kick of caffeine (or a milder stimulant like yerba mate).
Although rare, potential side effects of glucosamine supplements include: indigestion, nausea, heartburn, diarrhea, constipation, skin reactions and headaches. It’s not well known how glucosamine effects women during pregnancy or while breastfeeding, so it’s best to avoid taking supplements during those times unless being monitored. There’s also some evidence that glucosamine supplements (usually when taken in high doses) might have the potential to cause changes in cholesterol, insulin and blood sugar levels in people with diabetes or high cholesterol, so be careful if you fall into these categories and consider getting your doctor’s advice. ( 11 )