Undecylenic acid mechanism of action

In terms of the mechanism underlying its antifungal effects against Candida albicans , undecylenic acid inhibits morphogenesis. In a study on denture liners, undecylenic acid in the liners was found to inhibit conversion of yeast to the hyphal form (which are associated with active infection), via inhibition of fatty acid biosynthesis. The mechanism of action and effectiveness in fatty acid-type antifungals is dependent on the number of carbon atoms in the chain, with efficacy increasing with the number of atoms in the chain.

There are also many drug interactions . Patients must read in detail the enclosed data sheet(s) of the medicine. For example, the azole antifungals such as ketoconazole or itraconazole can be both substrates and inhibitors of the P-glycoprotein , which (among other functions) excretes toxins and drugs into the intestines. [20] Azole antifungals also are both substrates and inhibitors of the cytochrome P450 family CYP3A4 , [20] causing increased concentration when administering, for example, calcium channel blockers , immunosuppressants , chemotherapeutic drugs , benzodiazepines , tricyclic antidepressants , macrolides and SSRIs .

Optimal gastrointestinal tract functioning is vital to the absorption of nutrients, elimination of waste, and proper immune function.* Many health-care practitioners consider gut function and especially good gut ecology – maintaining a healthy balance of gut flora, the microorganisms that normally live in the digestive tract – to be a key component to overall health.* Many situations can contribute to an imbalance in the microbial flora of the digestive tract, including an unhealthy diet, inadequate digestive enzymes, oral contraceptives, and the use of various prescription and OTC drugs. Increasing recognition is also being given in women's health to the relationship between gut flora and vaginal flora; ., a healthy balance of gut flora has corresponding benefit to the vaginal flora.*

Fatty acids have been used for centuries to help maintain a healthy balance of the microorganisms that normally live in the gastrointestinal tract.* In the last 50 years, fatty acids have demonstrated effectiveness in supporting a healthy gut flora in a number of studies.*

Undecylenic acid (10-undecenoic acid) is an eleven-carbon, mono-unsaturated fatty acid occurring naturally in the body's perspiration. While several fatty acids have beneficial effects on the flora that naturally inhabit the gastrointestinal tract, undecylenic acid is the most potent.*

A Thorne Research innovation, Formula SF722 contains undecylenic acid in a base of pure, extra-virgin olive oil. Formula SF722 aids in the establishment of healthy gut and vaginal flora and has been one of Thorne Research's best-selling products for over two decades.*

Undecylenic acid mechanism of action

undecylenic acid mechanism of action

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