What causes testosterone loss

The potential for testosterone transfer from healthy males dosed with FORTESTA to healthy females was evaluated in a placebo-controlled, three-way crossover study . The washout period was approximately 29 days. Six males were treated with either FORTESTA (30 mg testosterone) or placebo to one thigh only. At 2 hours after the application of FORTESTA to males, the females rubbed their forearms for 15 minutes on the thigh of the males. Serum concentrations of testosterone were monitored in females for 24 hours after the transfer procedure. When direct skin-to-skin transfer occurred with FORTESTA mean Cavg increased by 134% and mean Cmax increased by 191%, compared to direct skinto- skin transfer with placebo. When transfer occurred with FORTESTA while covering a thigh with boxer shorts, mean Cavg decreased by 3% and mean Cmax increased by 2%, compared to direct skin-toskin transfer with placebo [see DOSAGE AND ADMINISTRATION ].

Infertility can result from a condition that is present at birth (congenital) or can develop later (acquired). Causes for infertility include the following:

  • Chemotherapy
  • Defect or obstruction in the reproductive system (., cryptorchidism, anorchism)
  • Disease (., cystic fibrosis, sickle cell anemia, sexually transmitted disease [STD])
  • Hormone dysfunction (caused by disorder in the hypothalamic-pituitary-gonadal axis)
  • Infection (., prostatitis, epididymitis, orchitis)
  • Injury (., testicular trauma)
  • Medications (., to treat high blood pressure, arthritis, etc.)
  • Metabolic disorders such as hemochromatosis (affects how the body uses and stores iron)
  • Retrograde ejaculation (., condition in which semen flows backwards into the bladder during ejaculation)
  • Systemic disease (., high fever, infection, kidney disease)
  • Testicular cancer
  • Varicocele

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What causes testosterone loss

what causes testosterone loss


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