Hi Thanks so much for all the useful posts on preservatives and I’m looking forward to your naturals class. This morning I overheard a conversation on the “dangers” of parabens. While I get the fear mongering and pseudo science that has surrounded this issue, there was one thing she said that made me wonder….Is there a potential danger from using too many products containing them? By my last count (and I’m somewhat embarrassed to admit this but apparently marketing works…) I use 45-48 products every morning….body wash, perfume, shampoo, conditioner, hair gels and thermal protecting hair sprays, lots of different makeup products, eye cream…deodorant.. serums….you name it. If every product contains parabens, could there be a health effect in that the amount on my body is no longer insignificant? Hope that makes sense. Thanks!
Resistance to ketoconazole has been observed in a number of clinical fungal isolates, including Candida albicans . Experimentally, resistance usually arises as a result of mutations in the sterol biosynthesis pathway. Defects in the sterol 5-6 desaturase enzyme reduce the toxic effects of azole inhibition of the 14-alpha demethylation step. Multidrug-resistance (MDR) genes can also play a role in reducing cellular levels of the drug. As azole antifungals all act at the same point in the sterol pathway, resistant isolates are normally cross-resistant to all members of the azole family.